Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1b
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چکیده
Fukata, Taiki Higo, Kensuke Egashira, Shosuke Takahashi, Kozo Kaibuchi and Akira Tadashi Kandabashi, Hiroaki Shimokawa, Kenji Miyata, Ikuko Kunihiro, Yoji Kawano, Yuko β Coronary Artery Spasm in a Porcine Model With Interleukin-1 Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.101.11.1319 2000;101:1319-1323 Circulation. http://circ.ahajournals.org/content/101/11/1319 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
BACKGROUND We recently demonstrated that the Rho-kinase-mediated pathway plays an important role for coronary artery spasm in our porcine model with interleukin-1beta (IL-1beta). In this study, we examined whether or not Rho-kinase is upregulated at the spastic site and if so, how it induces vascular smooth muscle hypercontraction. METHODS AND RESULTS Segments of the left porcine coronary art...
متن کاملLong-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.
OBJECTIVE We recently demonstrated that Rho-kinase/ROK/ROCK is functionally upregulated at the arteriosclerotic coronary lesions and plays a key role for coronary vasospastic responses in our porcine model with interleukin (IL)-1beta. In the present study, we tested our hypothesis that Rho-kinase is involved in the pathogenesis of coronary arteriosclerosis per se in our porcine model. METHODS...
متن کاملInvolvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.
Coronary artery spasm plays an important role in the pathogenesis of a wide variety of ischemic heart diseases. We have recently demonstrated that Rho-kinase plays a key role in the spasm in our porcine model. However, it remains to be elucidated whether Rho-kinase-mediated pathway also contributes to vasoconstriction of human arteries. From 15 patients who underwent coronary artery bypass oper...
متن کاملRho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
OBJECTIVE We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecular mechanism for and the phosphorylation sites for the enhanced MLC phosphorylations were unknown. In the present study, we addressed these points u...
متن کاملEvidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
OBJECTIVE We have recently demonstrated that protein kinase C (PKC) and Rho-kinase play important roles in coronary vasospasm in a porcine model. However, it remains to be examined whether there is an interaction between the two molecules to cause the spasm. METHODS AND RESULTS A segment of left porcine coronary artery was chronically treated with IL-1beta-bound microbeads in vivo. Two weeks ...
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